Technical Group Leader, Upstream Manufacturing - Biologics - Eurofins CDMO Alphora, Inc

Eurofins Voir toutes les offres

  • Mississauga, ON
  • Permanent
  • Temps-plein
  • Il y a 1 mois
Company DescriptionEurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins works with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate. Eurofins believes it is a global leader in food, environmental, pharmaceutical and cosmetics products testing and in agroscience CRO services. It is also one of the global independent market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, CDMO, advanced material sciences and in the support of clinical studies.In over 35 years, Eurofins has grown from one laboratory in Nantes, France to 61,000 staff across a decentralised and entrepreneurial network of ca. 900 laboratories in 61 countries. Eurofins companies offer a portfolio of over 200,000 analytical methods to evaluate the safety, identity, composition, authenticity, origin, traceability and purity of biological substances and products.In 2025, Eurofins generated total revenues of EUR 7.296 billion, and has been among the best performing stocks in Europe over the past 20 years.Eurofins CDMO Alphora Inc. develops and manufactures new therapeutics to improve the lives and health of patients. Eurofins CDMO Alphora provides contract research & development services to global pharmaceutical and biotech companies, developing their processes and manufacturing their bulk drug substances (Active Pharmaceutical Ingredients -“API's”) as well as finished dosage products (tablets, capsules, suspensions) for supply to clinical trials and commercial requirements. Eurofins CDMO Alphora provides a rich and technologically challenging environment with a continuing flow of interesting projects. Our employees work in close concert with clients throughout the development process to achieve their program objectives. Eurofins CDMO Alphora Inc. is growing its state-of-the-art organization, with continued investments in modern facilities, equipment, and instrumentation while providing a rich environment for employees to develop their technical skills and careers paths.Job DescriptionDrive Innovation. Lead Science. Shape the Future of Biologics.Are you ready to lead upstream innovation that directly drives successful GMP manufacturing? As our Technical Group Leader - Upstream, you will play a pivotal technical and leadership role within our Biologics Business Unit, guiding upstream process development from small-scale experiments to pilot-scale operations and technology transfer into GMP.In this hands-on, high-impact role, you will mentor and lead technical activities, oversee cell culture operations, design scale-up strategies, and ensure seamless transition of processes into the manufacturing suite. If you thrive at the intersection of science, operations, and leadership-this is your opportunity to make a measurable difference.The Technical Group Leader-Upstream is accountable for executing and reporting on upstream activities, including execution of small/pilot scale PD and scale-up experiments within the Biologics Business Unit to meet the business objectives. Our carefully selected candidate will play a crucial role for cell culture PD, which includes handling of various mammalian cell lines during seed expansion, operation of benchtop and large-scale single use (SU) bioreactors, and conducting harvesting for both depth and sterile filtration systems. In addition to hands-on laboratory activities, the ideal candidate will be involved in technology transfer, scale-up design, and writing experimental reports/protocols.At Eurofins CDMO Alphora Inc., our mission is to harness the power of biotechnology and bioprocessing to create innovative complex medicines that will improve the lives of patients worldwide. With a dedicated team of experienced scientists, motivated technologists, and state-of-the-art process development (PD) facility, we are thrilled to be at the forefront of the biopharmaceutical CDMO industry in Canada. Join us on this exciting journey as we push the boundaries of scientific research and provide hope to our most vulnerableWhat You'll Lead & DeliverYou will drive upstream activities that support process innovation, operational excellence, and successful clinical/commercial production and you will take ownership of:Technical Leadership & Process Development
  • Serve as the primary technical point of contact for transferring upstream processes from PD into GMP manufacturing.
  • Execute and oversee small- and pilot-scale upstream PD experiments, including seed expansion, buffer preparation, and bioreactor operations (benchtop & large-scale SU).
  • Lead technology transfer, scale-up designs, experimental protocols, and scientific reporting.
Hands-On Upstream Operations
  • Operate and maintain key upstream equipment: SU bioreactors, shaker incubators, cell counters, peristaltic pumps, mixers, and more.
  • Perform upstream experiments, harvests, depth filtration, and sterile filtration.
  • Apply expert aseptic techniques in all cell culture activities.
Documentation, Compliance & Technical Writing
  • Lead authoring of batch records, SOPs, equipment qualifications, and CQV protocols.
  • Ensure accurate documentation of all raw data (GDP/GLP), interpret results, and propose next-step experimentation.
  • Keep facility and equipment logbooks compliant with SOPs and cGMP standards.
Investigation & Continuous Improvement
  • Lead RCA investigations for process deviations and own CAPA development and execution.
  • Drive improvements in process robustness, operational efficiency, and data quality.
Cross-Functional Collaboration
  • Partner closely with QA, QC, DS Processing, and other Biologics teams to ensure smooth material flow and testing.
  • Support downstream operations, buffer prep, and other groups as needed.
GMP Operations & Suite Leadership
  • Oversee GMP upstream manufacturing activities and supervise floor operations.
  • Act as the suite's safety officer, ensuring safe, compliant equipment handling and PPE/ergonomic standards.
  • Maintain an always-inspection-ready environment, serving as an SME during audits and tours.
Materials, Equipment & Suite Readiness
  • Oversee ordering of materials, consumables, and equipment.
  • Coordinate calibration, PMs, and equipment readiness for all upstream unit operations.
  • Participate in suite cleaning and changeovers per CL2 and cGMP guidelines.
What Makes You a Great Fit
  • Strong technical expertise in mammalian cell culture and upstream bioprocessing.
  • Experience with scaling processes from benchtop to pilot/GMP manufacturing.
  • Excellent problem-solving, documentation, and leadership abilities.
  • Passion for hands-on science and guiding team members through complex activities.
Why This Role MattersYour leadership will directly influence the success of upstream process development and the transition of life-changing biologics into GMP manufacturing. This is a unique opportunity to combine scientific depth, operational leadership, and cross-functional impact.Qualifications
  • MSc or BSc in chemical/biochemical/bioprocess engineering or similar with minimum of five (5) years of industry experience is required.
  • Demonstrated experience in upstream bioprocessing (in biologics).
  • Experience in managing, supervising, and/or leading a team of technologists is a requirement.
  • Experience in technology transfer is a requirement.
  • Experience in SOP drafting and previous involvement in GMP runs is a requirement.
  • Strong interpersonal skills and ability to work collaboratively as a member of a cross-functional team.
  • Excellent communication, GMP documentation, and organizational skills.
  • Strong problem-solving skills
The starting annual base compensation for this position is $95,000 CAD. The actual offer, reflecting the total compensation package plus benefits, will be determined by a number of factors which include but are not limited to the applicant's experience, knowledge, skills, and abilities.Disclaimer: Salary information posted on sites other than the official careers page does not reflect the organization's compensation and may represent estimated ranges provided by third-party job boards. The organization offers competitive wages and a comprehensive total rewards package, which will be discussed during the interview process.At Eurofins CDMO Alphora, we leverage artificial intelligence (AI) technology to support our recruitment process, including preliminary screening of applications and resumes. All hiring decisions are made by human reviewers.This posting is for a current vacancy and the successful candidate will start as soon as possible.Additional InformationAt Eurofins we offer excellent full-time benefits including health & dental coverage, life and disability insurance, RRSP with 3% company match, paid holidays, paid time off.Accommodation: Persons with disabilities who need accommodation in the application process, or those needing job postings in an alternative format, may e-mail a request via the website at .As a Eurofins employee, you will become part of a company that has received international recognition as a great place to work. To learn more about Eurofins, please explore our website atWe thank all applicants within commuting distance of GTA, Ontario for showing an interest in this position. Only those selected for an interview will be contacted.NO AGENCIES, CALLS OR EMAILS PLEASE

Eurofins