Co-op Student, ADME/DMPK
- Vancouver, BC
- Permanent
- Temps-plein
Zymeworks is a publicly listed (NASDAQ:ZYME) R&D and clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation, bispecific and multifunctional biotherapeutics, focused on treatment of cancer and autoimmune diseases. Zymeworks' suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates. We are a global company headquartered in Vancouver, BC, with operations in Bellevue, WA, Dublin, Ireland, Singapore and Redwood City, CA.About the PositionWe are currently seeking a co-op student interested in ADME/DMPK to join the Analytics team. The successful candidate will be responsible for supporting in vitro profiling of potential drug candidates. The successful co-op student will frequently be challenged to critically analyze results and contribute to the Zymeworks team effort to create best-in-class therapeutics. This position reports to a Scientist in the Analytics group.This position will be based in Vancouver, BC. The candidates must be available to work on site without relocation assistance.The hourly wage for this co-op position is $21.00 CAD.What You'll Do
- The student is expected to participate in the design, validation, and implementation of ADME/DMPK assays to profile new drugs, drug-linkers, and antibody-drug conjugates:
- Implements and validates DMPK protocols for the characterization of new payloads and drug-linkers. For example:
- Plasma stability
- Lysosomal stability
- Kinetic solubility
- Plasma protein binding (PPB)
- Lysosomal trapping
- In vitro drug metabolism in different biological matrices
- Prepares samples (tissue preparation and extraction of analytes) for LC-MS analysis.
- Quantify drugs and/or drug metabolites using LC-MS/MSMS/HRMS and conducts data analysis using excel and GraphPad Prism.
- Performs experiments, interprets, and analyzes data, and prepares presentations for group meetings
- Administrative duties such as contributing to the writing of Standard Operation Procedures (SOPs)
- Conducts all activities in accordance with scientific standards, OS&H regulations, and established Zymeworks policies and practices
- Adheres to Zymeworks standard procedures for generating, documenting, and archiving data, maintaining an accurate, up-to-date electronic notebook
- Contributes to a safe and highly efficient laboratory environment through ordering of consumables, regular maintenance of reagent inventory, preparation of solutions, stocking of consumables, and maintaining a clean working environment
- Currently enrolled in an undergraduate program in Chemistry, Biochemistry, or Biotechnology.
- Availability for an 8-month co-op term is required.
- Proven interpersonal skills with the ability to work collaboratively as a member of cross-functional team. Ability to establish and maintain effective working relationships
- Good organizational skills and the ability to work effectively in a high-paced, fast-changing environment. Results-oriented mindset
- Experience with in vitro assays is preferred
- Experience with characterization of small molecules using HPLC-MS and some familiarity with operating these instruments outside of the teaching lab is preferred
- Excellent oral and written communication capabilities
- Good computer skills particularly with MS Office suite and ChemOffice (ChemDraw)